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:: Health Conditions - Cholesterol
- Purchase DHEA
DHEA - The Mother of all Hormones
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What
is DHEA?
DHEA (dehydroepiandrosterone) is a natural, intermediate steroid
hormone produced in our body by the adrenal glands. DHEA is
called "mother of hormones", or prohormone because
DHEA is further converted to generate 50 other essential hormones.
For example, DHEA is converted to androgens (male hormones)
or estrogens (female hormones) in the cells. DHEA is the most
abundant hormone in our blood, and adequate blood DHEA level
is critical for many vital hormonal and metabolic functions
of our body. Our bodies produce less and less DHEA as we age,
and as a result, our blood DHEA level decreases as we get
older, generally falling significantly by the age of 30, and
by as much as 50% by as 40.
Improved DHEA levels have been correlated with improved sense
of well being, reduce body fat and improve skin tone and moisture,
increase sex drive, improve immunity, enhance memory, and
increase bone density. Numerous studies have proven great
correlations between DHEA deficiency or insufficiency and
a variety of diseases and symptoms. For example, decreased
levels of DHEA predispose human and animals to higher probability
of breast cancer, autoimmune diseases, osteoporosis, and Alzheimer's
diseases, etc. A study reported in the prestigious journal
Science in August 2002 directly correlates increased blood
DHEA level to longevity.
DHEA dietary supplements have been in use for a variety of
reasons: To deter aging, improve sexual function/erectile
dysfunction, treat cognitive decline, enhance athletic performance,
facilitate weight loss, improve strength, treat osteoporosis,
improve immunomodulation for rheumatologic conditions, and
treat depression.
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History
DHEA was first isolated from urine by Adolf Butenandt in 1931,
who won Nobel prize for this. S-DHEA, the sulfate ester of
DHEA, was isolated in 1944. In 1960, Etienne-Emile Baulieu
discovered that HDEA is produced from adrenal cortex. During
the period of 1972-1991, DHEA was tested for the effectiveness
in reducing fat, protecting from cancers, and prevention of
atherosclerosis. DHEA began to show up as an OTC supplement
in early 1980, and was banned in 1985 by the US Food and Drug
Administration for lack of clinical data to support the safety
and medical claims made by the vendors. FDA's restrictions
on DHEA was lifted and DHEA remerged in the market in 1994
for distribution to public. DHEA has been a hot topic both
in commerce and research in the past two decades.
Usage
In general, DHEA dietary supplement is used to achieve the
following:
- Anti-Aging
- Enhanced mood, energy, and memory
- Improved immune system
- Boosted sex drive (especially in women)
- Reduced Osteoporosis.Improved fat loss
- More muscle mass
- Reduced Autoimmune disorders
- Less Heart Disease
Recommended dose has been estimated to be 30-60 mg per day,
although optimal dose has not been determined yet. Due to
the low efficiency of DHEA absorption through intestines,
varying proportions of the orally taken DHEA will not be delivered
to bloodstream. On the average, a 20 year old male produces
approximately 30 mg of DHEA per day, while an average female
produces 20 mg DHEA per day. Unless one takes excessively
large amount of DHEA on a regular basis, no side effect is
expected. Strange things have been reported to occur, although
rarely, at large-dose intake of DHEA: these include increased
facial hair, acne, increase perspiration, menstrual irregularity,
and adverse influence on prostate, etc.
DHEA Research:
Numerable scientific and clinical studies have been performed
on DHEA. Some reports and reviews on DHEA researches are provided:
- J Clin Endocrinol Metab 2002 Apr;87(4):1544-9 - Dehydroepiandrosterone
supplementation and bone turnover in middle-aged to elderly
men
- J Sex Marital Ther 2002 Jan-Mar;28(1):53-60 - Acute dehydroepiandrosterone
effects on sexual arousal in premenopausal women
- J Int Med Res 2002 Jan-Feb;30(1):9-14 - The effects of
cardiopulmonary bypass on androgen hormones in coronary
artery bypass surgery
- Arthritis Rheum 2002 Mar;46(3):654-62 - Inadequately low
serum levels of steroid hormones in relation to interleukin-6
and tumor necrosis factor in untreated patients with early
rheumatoid arthritis and reactive arthritis
- Anticancer Res 2001 Nov-Dec;21(6A):4051-4 - Serum dehydroepiandrosterone
(DHEA) and dehydroepiandrosterone sulfate (S-DHEA) and risk
of melanoma or squamous cell carcinoma of the skin
- J Sex Marital Ther 2002;28 Suppl 1:129-42 - Decreased
free testosterone and dehydroepiandrosterone-sulfate (DHEA-S)
levels in women with decreased libido
- Curr Opin Investig Drugs 2001 Aug;2(8):1045-53 - Novel
therapies in the treatment of systemic lupus erythematosus
- Eur J Endocrinol 2002 Mar;146(3):375-80 - Decreased steroidogenic
enzyme 17,20-lyase and increased 17-hydroxylase activities
in type 2 diabetes mellitus
- Metabolism 2002 Mar;51(3):376-9 - Effects of dehydroepiandrosterone
(DHEA) on rat apolipoprotein AI gene expression in the human
hepatoma cell line, HepG2
- J Clin Pharmacol 2002 Mar;42(3):247-66 - The influence
of hormones and pharmaceutical agents on DHEA and DHEA-S
concentrations: a review of clinical studies
- Endocr Regul 2001 Dec;35(4):217-22 - Circadian serum levels
of dehydroepiandrosterone sulphate in postmenopausal asthmatic
women before and after long-term hormone replacement
- J Med Assoc Thai 2001 Oct;84 Suppl 2:S605-12 - DHEA(S):
the fountain of youth
- Neuroscience 2002 Jan 28;109(2):243-51 - Dehydroepiandosterone
and its sulphate enhance memory retention in day-old chicks.

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